Биомаркеры сердечной недостаточности: современное состояние вопроса
https://doi.org/10.35401/2500-0268-2021-24-4-67-72
Аннотация
Ежегодно во всем мире наблюдается прирост числа пациентов с сердечной недостаточностью (СН). Ранняя диагностика состояния и прогнозирование неблагоприятного течения позволяют усовершенствовать тактику ведения пациентов и замедлить прогрессирование заболевания. В настоящий момент наиболее универсальным биомаркером СН считается предшественник мозгового натрийуретического пептида (NT-proBNP), однако и он обладает рядом недостатков. Поиск идеального биомаркера направлен в область молекулярной биологии и генетики. Микрорибонуклеиновые кислоты (микроРНК) выполняют в организме регулирующие функции, обладают кардиоспецифичностью и плазменной устойчивостью.
В ряде исследований микроРНК показали сопоставимую с NT-proBNP диагностическую и прогностическую ценность. Кроме того, потенциальные возможности метода не ограничиваются только диагностикой. МикроРНК могут также использоваться в качестве терапевтических мишеней лечения СН.
Об авторах
О. П. Ишевская
Кубанский государственный медицинский университет
Россия
Россия
Ишевская Ольга Петровна, аспирант кафедры терапии
№ 1 ФПК и ППС
350063, Краснодар, ул. М. Седина, 4,
А. М. Намитоков
Кубанский государственный медицинский университет; Научно-исследовательский институт – Краевая клиническая больница № 1 им. проф. С.В. Очаповского
Россия
Россия
Намитоков Алим Муратович, к. м. н., ассистент кафедры
терапии № 1 ФПК и ППС; заведующий кардиологическим отделением № 2 для больных с инфарктом миокарда
Краснодар
Е. Д. Космачева
Кубанский государственный медицинский университет; Научно-исследовательский институт – Краевая клиническая больница № 1 им. проф. С.В. Очаповского
Россия
Россия
Космачева Елена Дмитриевна, д. м. н., зав. кафедрой
терапии № 1 ФПК и ППС; заместитель главного врача по лечебной работе
Краснодар
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Рецензия
Для цитирования:
Ишевская О.П., Намитоков А.М., Космачева Е.Д. Биомаркеры сердечной недостаточности: современное состояние вопроса. Инновационная медицина Кубани. 2021;(4):67-72. https://doi.org/10.35401/2500-0268-2021-24-4-67-72
For citation:
Ishevskaia O.P., Namitokov A.M., Kosmacheva E.D. Biomarkers of heart failure: current state of problem. Innovative Medicine of Kuban. 2021;(4):67-72. (In Russ.) https://doi.org/10.35401/2500-0268-2021-24-4-67-72
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